Endocrine Abstracts

Introduction: The etiopathogenesis of obesity is represented by the endogenous circadian clock system, which has been shown to have a part in the regulation of body weight and energy homeostasis. The gene Circadian locomotor output cycles kaput (CLOCK) is part of the positive regulatory branch of the system. Polymorphism in CLOCK genes in human disorders characterized by alterations of endogenous circadian rhythms. Moreover, since in up to 30% of obese subjects seeking treatme...

Introduction: Ghrelin, enhances appetite and increases food intake in healthy humans. The endogenous ligand ghrelin is the GH secretagogue receptor (GHSR), and effects of ghrelin are mediated via GHSR. The GHSR system plays a significant role in regulating the process of obesity and type 2 diabetes that are linked to metabolic syndrome (MS). Therefore, the GHSR gene 171C/T (rs495225) polymorphism is a good candidate for susceptibility to obesity and excellent MS.<p class="...